Diversifying evolution of highly pathogenic H5N1 avian influenza virus in Egypt from 2006 to 2011
Identifieur interne : 001D86 ( Main/Exploration ); précédent : 001D85; suivant : 001D87Diversifying evolution of highly pathogenic H5N1 avian influenza virus in Egypt from 2006 to 2011
Auteurs : E. M. Abdelwhab [Allemagne, Égypte] ; Abdel-Satar Arafa [Égypte] ; Jürgen Stech [Allemagne] ; Christian Grund [Allemagne] ; Olga Stech [Allemagne] ; Marcus Graeber-Gerberding [Allemagne] ; Martin Beer [Allemagne] ; Mohamed K. Hassan [Égypte] ; Mona M. Aly [Égypte] ; Timm C. Harder [Allemagne] ; Hafez M. Hafez [Allemagne]Source :
- Virus Genes [ 0920-8569 ] ; 2012.
Abstract
Abstract: An evolutionary analysis was conducted of 354 hemagglutinin (HA) and 208 neuraminidase (NA) genes, including newly generated sequences of 5 HA and 30 NA, of Egyptian H5N1 clade 2.2.1 viruses isolated from poultry and humans. Five distinct phylogenetically distinguishable clusters arose from a monophyletic origin since 2006. Only two clusters remained in circulation after 2009: (i) A cluster of viruses arose in 2007 in industrial-vaccinated chickens and carried multiple mutations in or adjacent to the immunogenic epitopes of the HA. Viruses within this cluster evolved with significantly elevated mutation rates indicating persisting selective pressures, e.g. to escape host immunity and (ii) The second group arose in 2008 and harboured strains from recent human infections featuring a conspicuous deletion in the HA receptor-binding domain and substitutions close to the highly conserved active site of the NA. In both sublineages, a number of positively selected amino acids, different glycosylation patterns and variations in the polybasic proteolytic cleavage site were observed. Continuous monitoring of the evolving H5N1 virus in Egypt is essential to develop new control campaigns in poultry and human population.
Url:
DOI: 10.1007/s11262-012-0758-1
Affiliations:
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Hassan</name><affiliation wicri:level="1"><country xml:lang="fr">Égypte</country><wicri:regionArea>National Laboratory for Veterinary Quality Control on Poultry Production, Animal Health Research Institute, P.O. Box 246, 12618, Dokki, Giza</wicri:regionArea><wicri:noRegion>Giza</wicri:noRegion></affiliation></author><author><name sortKey="Aly, Mona M" sort="Aly, Mona M" uniqKey="Aly M" first="Mona M." last="Aly">Mona M. Aly</name><affiliation wicri:level="1"><country xml:lang="fr">Égypte</country><wicri:regionArea>National Laboratory for Veterinary Quality Control on Poultry Production, Animal Health Research Institute, P.O. Box 246, 12618, Dokki, Giza</wicri:regionArea><wicri:noRegion>Giza</wicri:noRegion></affiliation></author><author><name sortKey="Harder, Timm C" sort="Harder, Timm C" uniqKey="Harder T" first="Timm C." last="Harder">Timm C. 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Hafez</name><affiliation wicri:level="3"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute of Poultry Diseases, Free University of Berlin, Koenigsweg 63, 14163, Berlin</wicri:regionArea><placeName><region type="land" nuts="3">Berlin</region><settlement type="city">Berlin</settlement></placeName></affiliation></author></analytic><monogr></monogr><series><title level="j" type="main">Virus Genes</title><title level="j" type="abbrev">Virus Genes</title><idno type="ISSN">0920-8569</idno><idno type="eISSN">1572-994X</idno><imprint><publisher ref="https://scientific-publisher.data.istex.fr/ark:/67375/H02-SWLMH5L1-1">Springer US</publisher><pubPlace>Boston</pubPlace><note type="URL">http://www.springer-ny.com</note><date type="published" when="2012">2012</date><biblScope unit="vol" from="45" to="45">45</biblScope><biblScope unit="issue" from="1" to="1">1</biblScope><biblScope unit="page" from="14">14</biblScope><biblScope unit="page" to="23">23</biblScope></imprint><idno type="ISSN">0920-8569</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0920-8569</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Abstract: An evolutionary analysis was conducted of 354 hemagglutinin (HA) and 208 neuraminidase (NA) genes, including newly generated sequences of 5 HA and 30 NA, of Egyptian H5N1 clade 2.2.1 viruses isolated from poultry and humans. Five distinct phylogenetically distinguishable clusters arose from a monophyletic origin since 2006. Only two clusters remained in circulation after 2009: (i) A cluster of viruses arose in 2007 in industrial-vaccinated chickens and carried multiple mutations in or adjacent to the immunogenic epitopes of the HA. Viruses within this cluster evolved with significantly elevated mutation rates indicating persisting selective pressures, e.g. to escape host immunity and (ii) The second group arose in 2008 and harboured strains from recent human infections featuring a conspicuous deletion in the HA receptor-binding domain and substitutions close to the highly conserved active site of the NA. In both sublineages, a number of positively selected amino acids, different glycosylation patterns and variations in the polybasic proteolytic cleavage site were observed. Continuous monitoring of the evolving H5N1 virus in Egypt is essential to develop new control campaigns in poultry and human population.</div></front></TEI><affiliations><list><country><li>Allemagne</li><li>Égypte</li></country><region><li>Berlin</li><li>Hambourg</li></region><settlement><li>Berlin</li><li>Hambourg</li></settlement></list><tree><country name="Allemagne"><region name="Berlin"><name sortKey="Abdelwhab, E M" sort="Abdelwhab, E M" uniqKey="Abdelwhab E" first="E. M." last="Abdelwhab">E. M. Abdelwhab</name></region><name sortKey="Abdelwhab, E M" sort="Abdelwhab, E M" uniqKey="Abdelwhab E" first="E. M." last="Abdelwhab">E. M. Abdelwhab</name><name sortKey="Beer, Martin" sort="Beer, Martin" uniqKey="Beer M" first="Martin" last="Beer">Martin Beer</name><name sortKey="Graeber Gerberding, Marcus" sort="Graeber Gerberding, Marcus" uniqKey="Graeber Gerberding M" first="Marcus" last="Graeber-Gerberding">Marcus Graeber-Gerberding</name><name sortKey="Graeber Gerberding, Marcus" sort="Graeber Gerberding, Marcus" uniqKey="Graeber Gerberding M" first="Marcus" last="Graeber-Gerberding">Marcus Graeber-Gerberding</name><name sortKey="Grund, Christian" sort="Grund, Christian" uniqKey="Grund C" first="Christian" last="Grund">Christian Grund</name><name sortKey="Hafez, Hafez M" sort="Hafez, Hafez M" uniqKey="Hafez H" first="Hafez M." last="Hafez">Hafez M. Hafez</name><name sortKey="Harder, Timm C" sort="Harder, Timm C" uniqKey="Harder T" first="Timm C." last="Harder">Timm C. Harder</name><name sortKey="Stech, Jurgen" sort="Stech, Jurgen" uniqKey="Stech J" first="Jürgen" last="Stech">Jürgen Stech</name><name sortKey="Stech, Olga" sort="Stech, Olga" uniqKey="Stech O" first="Olga" last="Stech">Olga Stech</name></country><country name="Égypte"><noRegion><name sortKey="Abdelwhab, E M" sort="Abdelwhab, E M" uniqKey="Abdelwhab E" first="E. M." last="Abdelwhab">E. M. Abdelwhab</name></noRegion><name sortKey="Aly, Mona M" sort="Aly, Mona M" uniqKey="Aly M" first="Mona M." last="Aly">Mona M. Aly</name><name sortKey="Arafa, Abdel Satar" sort="Arafa, Abdel Satar" uniqKey="Arafa A" first="Abdel-Satar" last="Arafa">Abdel-Satar Arafa</name><name sortKey="Hassan, Mohamed K" sort="Hassan, Mohamed K" uniqKey="Hassan M" first="Mohamed K." last="Hassan">Mohamed K. Hassan</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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